Kidney Damage in Solid Tumors

Harmine recover kidney damage induced by morphine in male rats

Harmine is a harmal-derived alkaloid with antioxidant properties. The morphine produces free radicals and plays a key role in the pathogenesis of kidney disease. This study was designed to evaluate the effects of harmine against morphine- induced damage to the kidneys of rats. In this study, 64 male rats were randomly assigned to 8 groups: saline and morphine treated groups; harmine groups (5, ...

Meningeal carcinomatosis in solid tumors.

The involvement of the leptomeninges by metastatic tumors can be observed in solid tumors, in which case it is termed meningeal carcinomatosis (MC), and in lymphoproliferative malignant disease. It is more common in breast and lung cancer, as well as melanoma, with adenocarcinoma being the most frequent histological type. MC is usually a late event, with disseminated and progressive disease alr...

Oncogene Addiction in Solid Tumors

Genealogies in Growing Solid Tumors

Over the past two decades, the theory of tumor evolution has largely focused on the selective sweeps model. According to this theory, tumors evolve by a succession of clonal expansions that are initiated by driver mutations that have a fitness advantage over the resident types. A 2015 study of colon cancer [44] has suggested an alternative theory of tumor evolution, the so-called Big Bang model...

Symposium on Solid Tumors

Malignant melanoma Is an a^resslve, therapy-resistant malignancy of melanocytes. The incidence of meianoma has l>een steadily increasing worldwide, resulting In an increasing pubiic health problem. Exposure to solar UV radiation, fair skin, dysplastlc nevi syndrome, and a family history of meianoma are major risk factors for melanoma development. The interactions between genetic and environment...